Brand Story
24 Jan 2023, 05:59 GMT+10
Despite there being 124 FDA-approved new medications accessible for solid cancer therapy, a recent study indicated that the overall survival and progression-free survival rates for patients with solid cancer indications had grown only by 1.97-4.60 months and 1.50-5.58 months, respectively. Current cancer treatments largely target the secondary tumours of metastatic cancer rather than the metastasis process, which results in 90% of cancer deaths. This lack of progress in cancer treatment is primarily attributable to this approach.
Arnab Roy Chowdhury, PhD, the founder and director of Mestatop Solutions, a cancer research company, and his team of researchers have created a number of cutting-edge platforms that seek to understand better and target the metastasis process in cancer treatment in order to address this problem. These platforms consist of METVivo, METSCAN, and METAssay.
The METAssay platform uses 30 cellular assays to analyse the distinctions between tumour cells that are developing and those that are metastasizing along the whole metastatic pathway. This helps uncover potential therapeutic targets and gives researchers a better grasp of the biology behind cancer spread.
The METSCAN platform is an addition to the METAssay platform that includes data from patient samples, advancing translational relevance. A preliminary clinical trial for METSCAN's algorithm, which can assist in predicting the metastatic potential of primary tumours to spread, is now being conducted.A time-sensitive animal model, the METVivo platform offers quicker turnaround and more reliable findings. The more accurately the model represents the human disease, the more realistic conditions can be used to test the most promising therapy possibilities.
These platforms have already demonstrated encouraging outcomes in a case study, where 2 hits were advanced for translational analysis of several patient samples, leading to outstanding ex-vivo efficacy in reducing metastasis without changing tumour size. The team also conducted a retrospective analysis that demonstrated the potential therapeutic significance of repurposing already-approved medications to treat metastasis; the rank ordering of the retrospective clinical trial of medications correlated with the rank ordering of the METAssay.
According to Chowdhury, his team is capable of selecting the top compounds from any library with anti-metastasis activity, positioning anti-cancer leads/candidates for metastasis, and repurposing authorised medications for the treatment of metastasis. They can adapt this platform to understand the biology of various tissue-specific cancers and their spread. Still, their current work focuses on colorectal, head and neck, and triple-negative breast tumours. The Chowdhury team is sure that their unique strategy will open the door for the creation of novel medications and treatments that will increase cancer patients' chances of survival and quality of life.
Read the source story on CNBC. - New cancer treatment platforms show promising results in targeting metastasis
Get a daily dose of Albuquerque Express news through our daily email, its complimentary and keeps you fully up to date with world and business news as well.
Publish news of your business, community or sports group, personnel appointments, major event and more by submitting a news release to Albuquerque Express.
More InformationWASHINGTON D.C.: The Biden administration said this week that it will end US COVID-19 emergency declarations on 11th May, nearly ...
WASHINGTON D.C.: In a letter to lawmakers last week, the US Federal Aviation Administration (FAA) said it had put in ...
WASHINGTON D.C.: The Biden administration has stopped issuing export licenses to US companies seeking to ship most items to China's ...
Nearly a year in, the war in Ukraine has cost tens of thousands of lives and brought the world to ...
WASHINGTON D.C.: The US House of Representatives has passed a bill that limits the ability of US Energy Secretary Jennifer ...
BOSTON, Massachusetts: Russian businessman Vladislav Klyushin, who has ties to the Kremlin, has been accused of making tens of millions ...
SANTA CLARA, California: One week after Intel forecasted lower-than-expected sales caused by a loss of market share to rivals and ...
WASHINGTON D.C.: As part of a wider policy drive to increase competition in consumer markets, President Joe Biden has announced ...
OSLO, Norway: Ending a three-year run of profits as stock and bond prices were hit by rising inflation and Russia's ...
NEW YORK, New York - Strong economic data failed to stem profit-taking on the major U.S. bourses on Friday, while ...
WASHINGTON D.C.: The US has again asked Mexico to investigate claims that workers at an auto parts facility of American ...
WASHINGTON D.C.: Tesla confirmed this week that the US Justice Department has requested documents related to its Full Self-Driving and ...